When Patrick Quickly-Shiong, the billionaire businessman, medical researcher and proprietor of the Los Angeles Occasions, opened a $250mn vaccine facility in Cape City in 2022, he was requested by Geordin Hill-Lewis, the town’s mayor, why he had chosen the Western Cape capital to make his funding.
In any case, Quickly-Shiong, a South African-born US citizen and entrepreneur, was introduced up in Port Elizabeth, studied on the College of Witwatersrand in Johannesburg and constructed his enterprise empire in California, Hill-Lewis explains.
“His instantaneous response was, ‘It’s the colleges. I want a gradual provide of younger scientists and engineers and I can get them in Cape City,’” Hill-Lewis provides, recounting his assembly with Quickly-Shiong on the vaccine facility’s inauguration occasion attended by South Africa’s President Cyril Ramaphosa. “I believed that was a terrific comment.”
In addition to the College of Cape City, steadily ranked as one of the best on the continent, the town has different revered establishments of upper studying, together with the Cape Peninsula College of Expertise, the College of the Western Cape and, simply up the street within the wine area, Stellenbosch College.
Just like the Cambridge-Oxford cluster within the UK, or Boston within the US, Cape City’s focus of universities permits a gradual stream of PhD and different analysis to be spun out into firms, making the town considered one of Africa’s foremost start-up hubs, buyers say.
One instance is H3D, an built-in drug-discovery centre based by Kelly Chibale, a Zambian professor of natural chemistry on the College of Cape City.
In 2017, H3D grew to become the primary analysis centre on the continent to place an “African drug” — an antimalarial — into section II medical trials. Final 12 months, earlier than the medical analysis funding atmosphere was hit by cuts to the US Company for Worldwide Growth and the Nationwide Institutes of Well being, it was using 75 researchers, most of them with doctorates.
Cape City has additionally benefited from a broader development in South Africa, often called “semigration” wherein rich folks from Gauteng province, the economic heartland, in addition to poorer ones from Japanese Cape, flock to a metropolis that’s recognized for having higher infrastructure and companies than Johannesburg, the nation’s financial capital.
Whereas that brings issues, corresponding to pushing up rents and home costs, it additionally provides to Cape City’s cluster impact. Amongst these shifting are banks and different monetary establishments, which have both moved their headquarters to Cape City or have seen growing numbers of workers relocate to the town.
“There’s been such a migration of the monetary companies business in South Africa to Cape City that there’s a rising ecosystem of enterprise capital finance obtainable right here, which I believe helps the tech and start-up ecosystem,” Hill-Lewis says.
Mia von Koschitzky-Kimani, companion at Future Africa, which invests in early start-ups, lately moved from Nairobi to Cape City seeking funding alternatives. Although it’s early days, she says, her first impression of the town’s start-up scene is that it is vitally completely different from those in Kenya and Nigeria.
In South Africa, she says, most of the founders are white, with Black South Africans — for thus lengthy excluded from enterprise alternatives by racist apartheid legal guidelines — preferring to work within the public sector or for established firms. Her hunch is that Black-owned start-ups battle to entry worldwide capital, which doesn’t essentially goal South Africa, a notionally richer nation than most in Africa, which means that some companies could also be undervalued.
One other distinction is that, whereas Nigerian start-ups are most frequently created to unravel issues of logistics, finance and day by day residing in Nigeria, most of the companies in Cape City are addressing a world market, Koschitzky-Kimani says. Among the pitch decks she receives are technically very refined, she provides, indicating a sure degree of ability and an ambition to unravel world issues.
“The quintessential South African entrepreneurs are constructing for South Africa or excited about the world outdoors Africa,” she says. “They assume that Mexico is likely to be nearer to South Africa than Lagos — and in some methods they is likely to be proper.”

Cape City, with its relaxed way of life and proximity to mountains and sea, in addition to world-class vineyards, has additionally benefited from the development in digital nomads. South Africa’s authorities lately lowered the minimal earnings thresholds for the visa that enables candidates to base themselves within the nation for as much as three years, although many distant staff merely pitch up and enter the nation as vacationers.
“Lots of people are right here for good, or for six months a 12 months when the climate is sweet, however they’ve groups elsewhere on the earth,” says Koschitzky-Kimani. “We don’t see that in Lagos, and solely a little bit in Nairobi.”
Opus, a group of founders “from concepts to collection A”, has additionally simply arrange in Cape City, in addition to in Johannesburg. Jono Extra, Opus’s South African lead, says the boundaries to entry for start-ups have dropped massively, notably due to advances in synthetic intelligence, which implies there are generally too many early-stage companies chasing too few alternatives.
“There’s undoubtedly an enormous entrepreneurial buzz in Cape City,” he says. “However it’s extremely laborious to get funding. You may’t simply knock on the door and get a gathering.”
Extra has met dozens of firms in each Cape City and Johannesburg, starting from fintechs to at least one turning black soldier flies into pet meals. “It’s a really various group,” he says, pushing again on the concept that founders are principally white. “There are from all walks of life, all colors, ethnicities, religions, and genders,” he says. “They name us the Rainbow Nation. I’m witnessing that initially hand.”